Anne-Lise
Børresen-Dale
Mini CV
Academic Degrees.
- 1970 M.S. Biochemistry, Technical University of Norway, Trondheim, Norway.
- 1978 Doctor of Science in Medical Biochemical Genetics, University of Oslo, Norway.
- 1987 Judged qualified as a professor in gene technology, University of Oslo, Norway.
- 1992 Professor in Molecular Tumorbiology, Univ. of Oslo, Norway (still holding)
- 2000 Professor in Molecular Oncology, Univ. of Bergen, Norway (still holding)
- 1970-72 Research assistant, Institute of Medical Genetics, University of Oslo.
- 1972-78 Research Fellow, Institute of Medical Genetics, University of Oslo.
- 1978-82 Senior Research Fellow, Institute of Medical Genetics, University of Oslo
- 1982-86 Senior Biochemist, head of biochemical section for prenatal diagnosis, Department of Genetics, UiO.
- 1987-99 Senior Scientist, Dept. of Genetics, Inst. for Cancer Research, DNR, Norway
- 1993-99 Head of DNA Diagnostic Service Lab, DNR, Oslo, Norway.
- 1999-dd Head of Department, Dept. Genetics, Inst. for Cancer Research, DNR, Norway.
- 1989 Prof. Olav Torgersens Prize and Memorial Lecture, Title: Gene technology in the fight against cancer.
- 1989 Honorary lecturer at the 175th anniversary of the Medical Faculty, Univ. of Oslo.
Title: Genes, inheritance and cancer; gene technology in cancer diagnosis and prevention. - 1994 King Olav V's Cancer Research Prize
- 1998 Elected member of: “Det Kongelige Norske Videnskabers Selskab”
- 2001 Honorary member of The Norwegian Biochemical Society
- 2002 University of Oslo’s Research Prize for Outstanding Research
- 2002 Salhus Ansvar Medical prize for Outstanding Research in Tumorbiology
- 2002 The Employer of the year at The Norwegian Raduimhospital
From 1972 to 2002 I have worked from 1-4 months as a Visiting scientist in different laboratories in US and Europe. These are: 1) Dep. Hum.Biol.Chem& Gen, Univ. Texas, (1972, Barbara Bowman), protein sequencing. 2) The Rockefeller University, New York (1977, Thomas Kindt), protein sequencing, 3) EMBL (1985, Hans Lerach), studying recombinant DNA techniques, 4) Recombinant DNA Tech. Lab, Helsinki, Finland (1986, Leena Peltonen), 5) Harvard Med. Sch., Mass. (1990, David Yandell), PCR/SSCP on Rb, 6) MIT, Cent. Envir. Health Sci. MA (1992, William Thilly), mutation assay systems, 7) MGH Cancer C. and Harvard Med. Sch, Boston, MA (1992, Stephen Friend) cloning strategies with relevance to Ataxia Telangiectasia and TP53. 8) Four months sabbatical as Visiting Professor, spring 2002 at Dept of Genetics, Stanford University, CA (David Botstein), Microarray analyses.
Administrative Experience
No formal education in leadership, but have followed courses in "Group leader management" arranged by UiO and DNR. Have had several positions where strategic planning was needed. Head of the DNA section at the Department of Genetic since 1987 and have built up a research group consisting of 24 persons. In 1999 I became the Chairman of the Department of Genetics with the administrative and scientific responsibility for at present 36 employers. Took the initiative to start a DNA diagnostic lab at the Department of Pathology and was up to 1/1-99 in charge of the Molecular Biology section of this lab.
Have initiated many scientific projects with both national and international collaborations as well as several international meetings and courses and have been chairman of several of them. Elected to many committees and have also chaired and are still chairing several. In 1989 I took the initiative to start a Nordic technology development project partly financed by Nordisk Industrifond (Total cost of the project was 10.2 mill NKr.). Was the principal investigator in this project for three years with participating groups in Sweden, Finland, Denmark and Iceland. In this project the mutation analyses system (CDGE) was developed in my lab, and was explored in the different collaborating groups, which all had different applications for the technology. The project also had industrial partners, and resulted in the collaboration with BIORAD and the development of the commercial system DGENE/DCODE that is now sold worldwide.
Have been on the steering Committee of the European Breast Cancer Linkage consortium for 6 years. This Consortium has had EU grants for two three year-periods, ending 1/1-99. Many publications have come from this collaboration. The network established is still working and many further collaborative projects are still ongoing. Took the initiative to start planning for a new EU-grant in the 6th framework on radiation exposure and breast cancer risk this fall. Are one of the PI`s in the large multicenter study WECARE financed by NCI/NIH.
A new EU Integrated project on “Mutant TP53 and and Cancer” has been ranked as no. 1 of 116 in the Cancer aerea with funding from 2004. I am one of the 16 partners in this project with the aim of doing tumor analyses.
Member of The Norwegian Radiumhospital`s Scientific Board "Forskningutvalget" since 1996, where new projects are evaluated and strategic planning for the Hospital is performed. Served as first deputy member of the "Akademiske Kollegium" at the University of Oslo for 3 years since 1999.
In 1987 I was one of the founders of a small Biotech company, Med Probe AS. Served as a Director for research and development for several years, and are still a board member. The company employs today 12 persons and had total revenue in 2003 of approxim. 35 mill NKr.
Have been on the evaluation committee for 9 professorships (3 international) and 21 doctoral thesises (4 international) in addition to reviewing several international grant applications. Have also served on a number of other committees, both national and international, the most important are listed below:
National:
1986-91 Secretary General, The Norwegian Biochemical Society.
1988 95 Board Member of the Research Council of The Norwegian Cancer Society.
1987 94 Council Member of The Norwegian Research Council for Science and Humanities.
1990 95 Vice chairman of the Board of DNR and Institute for Cancer Research.
1993-99 Board member of the Steering com. of the Concerted Action on Hereditary Breast Cancer.
1995-00 Chairman of expert committee on Biotech. And Genetics. Norwegian Board of Health.
1995-00 Chairman of the program committee, MedKap NFR
1999- 01 First deputy member of the Academic Collegium UiO
2000-01 Member of a deliberation committee for commercialization from academia, Ministry of education and
Research affairs, KUF (Bernt utvalget ).
2001- Board member of the National Committee for Functional Genomics, FUGE
International
1992-93 Member of Discipline Oriented Group (DOG) Commission of the European Committee. (EU)
1996-98 Member of Fellowship Selection Committee, International Agency for research of Cancer, IACR, Lyon.
1999- Member of the Scientific Council, International Agency for Research of Cancer, IARC, Lyon
2002- Vice Chairman of the Scientific Council, IACR, Lyon
2000- Member of International Affairs Committee, American Association for Cancer Research, AACR
2001 Member of the Pezcoller Prize Committee, AACR/Italian Cancer Society
2002 Member of the Selection Committee for the Women in Cancer Research Award, AACR
2002 Site Visiting and Evaluation Committee for Cancer Research UK to Cambridge Cancer Center, UK
2002 Chairperson of a subcommittee of the 2003 AACR Program Committee
2003- Member of The Board of Directors, American Association for Cancer Research (AACR)
Editorial boards:
Pharmacogenetics (to 1999), British Journal of Cancer (to 2000), Human Mutation (corresponding editor), Biotechniques, Breast Cancer Research, Journal of the Norwegian Medical Association, Molecular Cancer Research, Public Library of Science (PloS).
Teaching responsibilities and course organization
Formal pedagogical education from UiO, a basic course in University Pedagogic in 1976 and one advances course in 1983. Since 1975 lecturer for medical students in biochemical genetics and gene technology and lecturer for science students in molecular genetics at UiO, both at undergraduate and graduate level. Since 1997 a PBL (problem based learning) teacher for medical students in cell biology and genetics.
I have been the main supervisor of 16 PhD degrees (12 completed) and 12 undergraduates (10 completed).
Since 1997 I have been on the organizing committees of more than 20 different meetings and symposia, both national and international. The most important, where I also was the chairman is listed below:
1992 : Chairman and organizer: EMBO Adv. Course on: "Detection of base mutation in the human genome".
1995 and 2000: Chairman and organizer; 1st and 2nd International Symposium on the Molecular Biology of
Breast Cancer.
Current Research Projects
Molecular genetic studies of breast and ovarian cancer. Identification of genotypes and gene expression profiles
contributing to elevated cancer risk, radiation sensitivity, tumour aggressiveness and therapy resistance.
Publications:
Author of 250 scientific papers in international reviewed journals, 20 chapters/reviews, 31
Nordic or popular scientific articles.
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