Identification of genomewide expression profiles related to tumor type, stage and aggressiveness, and to therapy response using DNA microarrays
Post doc Therese Sørlie is the main investigator in this project.
In close collaboration with David Botstein and Partric Brown at Stanford University, who developed the cDNA microarray technology we have so far analyzed the expression profile of more than 300 breast tumors. The gene expression patterns observed in different tumor samples from the same individual are almost always more similar to each other than to any other sample giving each tumor a distinct molecular portrait. Collections of co-expressed genes have been identified for which variation in mRNA levels could be related to specific features of physiological variation, or to variation in the cellular constituents of the tumors. The tumors could be classified into subtypes that were distinguished by pervasive differences in their gene expression patterns and with different clinical outcome.
Link to Stanford collaboration.
Several tumor series from breast cancer patients, consecitive series, early stage tumors,selected series of different histological types, as well as tumors from patients on different clinical trials are being expression profiled using both the Stanford 43K cDNA microarrays, as well as the arrays produced in the Core Facility at DNR.
Other persons involved in different aspects of this project are PhD students Anita Langerød and Anna Bergamaschi and Medical technologist Hilde Johnsen.
The ovarian cancer studies are performed by PhD student Yun Wang in collaboration with Post doc Åslaug Helland.
Other close collaborators at Stanford are Stefanie Jeffrey and Marci Schaner.
In close collaboration with David Botstein and Partric Brown at Stanford University, who developed the cDNA microarray technology we have so far analyzed the expression profile of more than 300 breast tumors. The gene expression patterns observed in different tumor samples from the same individual are almost always more similar to each other than to any other sample giving each tumor a distinct molecular portrait. Collections of co-expressed genes have been identified for which variation in mRNA levels could be related to specific features of physiological variation, or to variation in the cellular constituents of the tumors. The tumors could be classified into subtypes that were distinguished by pervasive differences in their gene expression patterns and with different clinical outcome.
Link to Stanford collaboration.
Several tumor series from breast cancer patients, consecitive series, early stage tumors,selected series of different histological types, as well as tumors from patients on different clinical trials are being expression profiled using both the Stanford 43K cDNA microarrays, as well as the arrays produced in the Core Facility at DNR.
Other persons involved in different aspects of this project are PhD students Anita Langerød and Anna Bergamaschi and Medical technologist Hilde Johnsen.
The ovarian cancer studies are performed by PhD student Yun Wang in collaboration with Post doc Åslaug Helland.
Other close collaborators at Stanford are Stefanie Jeffrey and Marci Schaner.
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