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Petras Juzenas
Position: Scientist
Phone: +47-22781205
Email:
 

Mini CV

Current Position: since 2006 - Scientist at the Department of Radiation Biology.

Main interest:
Nanomedicines for cancer detection and therapy

Contact information:
Address: Department of Radiation Biology, Room J4004
Institute for Cancer Research, Norwegian Radium Hospital
Ullernchausseen 70, Montebello 0310, Oslo, Norway
Tel.: +47 22 78 12 05
Fax: +47 22 78 12 07
Email: petras.juzenas[a]rr-research.no
Internet: http://radium.no/juzenas

Previous positions and education:
* 2003-2005: Postdoc financed by the Norwegian Cancer Society (Kreftforeningen) in the “Group of Biophysics and PDT” (group leader Prof. J.Moan).
* 2002: Ph.D. at the University of Oslo (supervisor Prof. Ph.D. J.Moan).
* 1999-2002: Research fellow and Ph.D. student at the Institute for Cancer Research.
* 1999, 2000: Research visits (1-2 months) at the Notre-Dame Hospital (Montreal, Canada).
* 1998: Guest researcher financed by the Research Council of Norway (Forskningsrådet) at the Department of Biophysics of the Institute for Cancer Research.
* 1997-2000: Scientific assistant and doctoral student at the University of Vilnius (Lithuania).
* 1995-1997: Specialist at the state power enterprise "AB Lietuvos Energija".
* 1995: University degree in physics at the Faculty of Physics, University of Vilnius.
* 1988-1990: Extramural School of Young Physicists "Fotonas" (Siauliai University, Lithuania).
* 1979-1990: Secondary School in Vilnius, Lithuania. Class with profound teaching in physics, mathematics and English (1983-1990).

Research fields
* Spectroscopy, photobiophysics and photobiology (since 1993);
* ALA-PDT: Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) (since 1998);
* Bionanotechnology and nanomedicines (since 2005).
* Ultrasound mediated drug release from liposomes (2006–2007).

Awards:
* 2004: Award received from the European Society for Photobiology (ESP) to attend the 14th International Congress on Photobiology (ICP 2004) in Jeju, Korea, June 10-15, 2004.
* 2001: Award received, together with the colleagues from PDT group (leader Prof. J.Moan), for the work “A new cancer-protecting and pigmenting suncream” granted in the “Venture Cup 2001” competition organised by Oslo Research Park.
* 1995: The report “Spectroscopy of photodrugs in vitro and in vivo” prepared together with a colleague A.Jasaitis, Jr. (group of Prof. R.Rotomskis) was awarded diploma and prize in annual competition of the Lithuanian Academy of Sciences for students' works.

Memberships
* European Society for Photobiology (ESP, since 2001);
* Norwegian Society for Photobiology and Photomedicine (NOFFOF, since 2002);
* American Society for Photobiology (ASP, since 2003);
* Norwegian NanoMedicine Network (since 2007);
* European Platform for Photodynamic Medicine (EPPM, since 2008);
* European Technology Platform on Nanomedicine (ETPN, since 2008).

Other activities and interests
* Member of the organizing committee of the “Nordic Workshop: ALA and ALA derivatives in diagnosis and therapy of cancer”, Kongsvold, Norway, March 15-17, 2002.
* Webmaster of the “Biophysics and PDT group” Internet site (2002-2007).
* Webmaster of the “Quantum Dots group” Internet site (since 2008).

Scientific publications (2009-1995):
67. P.Juzenas, A.Juzeniene, V.Iani, J.Moan (2009) Depth profile of protoporphyrin IX fluorescence in an amelanotic mouse melanoma model. Photochem. Photobiol. 85(3), 760-764.
66. R.F.Donnelly, P.A.McCarron, R.Al-Kassas, A.Juzeniene, P.Juzenas, V.Iani, A.D.Woolfson and J.Moan (2009) Influence of formulation factors on PpIX production and photodynamic action of novel ALA-loaded microparticles. Biopharmaceut. Drug Dispos. 30(2), 55-70.
65. P.Juzenas, W.Chen, Y.-P.Sun, M.A.N.Coelho, R.Generalov, N.Generalova, I.L.Christensen (2008) Quantum dots and nanoparticles for photodynamic and radiation therapy of cancer. Adv. Drug Deliv. Rev. 60(15), 1600-1614 (cover image of Dec. 2008 issue).
64. P.Juzenas, R.Generalov, A.Juzeniene, J.Moan (2008) Generation of nitrogen oxide and oxygen radicals by quantum dots. J. Biomed. Nanotech. 4(4), 450–456.
63. R.F.Donnelly, D.I.Morrow, P.A.McCarron, A.D.Woolfson, A.Morrissey, P.Juzenas, A.Juzeniene, V.Iani, H.O.McCarthy, J.Moan (2008) Microneedle arrays permit enhanced intradermal delivery of a preformed photosensitizer. Photochem. Photobiol. 85(1), 195-204.
62. R.F.Donnelly, D.I.Morrow, P.A.McCarron, A.D.Woolfson, A.Morrissey, P.Juzenas, A.Juzeniene, V.Iani V, H.O.McCarthy, J.Moan (2008) Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: potential for enhanced topical photodynamic therapy. J. Control. Release 129(3), 154-162.
61. A.Bugaj, M. Kwitniewski, V. Iani, A. Juzeniene, P. Juzenas, L.W. Ma and J. Moan (2007) Photodynamic therapy with di-L-arginine protoporphyrinate on WiDr human colon adenocarcinoma xenografts in athymic nude mice. Photodiagn. Photodyn. Ther. 4, 237-241.
60. A.Juzeniene, P.Juzenas, V.Iani, J.Moan (2007) Topical applications of iron chelators in photosensitization. Photochem Photobiol Sci. 6(12), 1268-1274.
59. M.Kaliszewski, M.Kwasny, A.Juzeniene, P.Juzenas, A.Graczyk, L.-W-Ma, V.Iani, P.Mikolajewska and J.Moan (2007) Biological activity of 5-aminolevulinic acid and its methyl ester after storage under different conditions. J. Photochem. Photobiol. B:Biol. 87(2), 67-72.
58. A.Juzeniene, P.Juzenas, L.W.Ma, V.Iani, J.Moan (2006) Topical application of 5-aminolaevulinic acid, methyl 5-aminolaevulinate and hexyl 5-aminolaevulinate on normal human skin. Br. J. Dermatol. 155(4), 791-799.
57. A.Juzeniene, P.Juzenas, I.Bronshtein, A.Vorobey and J.Moan (2006) The influence of temperature on photodynamic cell killing in vitro with 5-aminolevulinic acid. J. Photochem. Photobiol. B:Biol. 64, 161-166.
56. R.F.Donnelly, P.Juzenas, P.A.McCarron, L.-W.Ma, A.D.Woolfson and J.Moan (2006) Influence of formulation factors on methyl-ALA-induced protoporphyrin IX accumulation in vivo. Photodiagn. Photodyn. Ther. 3(3), 190-201.
55. R.F.Donnelly, L.W.Ma, P.Juzenas, V.Iani, P.A.McCarron, A.D.Woolfson and J. Moan (2006) Topical bioadhesive patch systems enhance selectivity of protoporphyrin IX accumulation in tumours. Photochem. Photobiol. 82(3), 670-675.
54. P.Juzenas, A.Juzeniene, V.Iani and J.Moan (2006) The influence of light and darkness on cutaneous fluorescence in mice. Luminescence 21(3), 159-163.
53. M. von Beckerath, P.Juzenas, L.Löfgren, L.-W.Ma, V.Iani, Z.Malik and J.Moan (2006) Influence of physiological parameters on the production of protoporphyrin IX in human skin by topical application of 5-aminolevulinic acid and its hexylester. J. Med. Sci. 6(4), 546-553.
52. A.Veberg, O.Sørheim, J.Moan, V.Iani, P.Juzenas, A.N.Nilsen and J.P.Wold (2006) Measurement of lipid oxidation and porphyrins in high oxygen modified atmosphere and vacuum-packed minced turkey and pork meat by fluorescence spectra and images. Meat Sci. 73(3), 511-520.
51. Z.Luksiene, P.Juzenas, and J.Moan (2006) Radiosensitization of tumours by porphyrins. Cancer Lett. 235(1), 40-47.
50. A.Bugaj, A.Juzeniene, P.Juzenas, V.Iani, L.W.Ma and J.Moan (2006) The effect of skin permeation enhancers on the formation of porphyrins in mouse skin during topical application of the methyl ester of 5-aminolevulinic acid. J. Photochem. Photobiol. B:Biol. 83(2), 94-97.
49. A.Bugaj, V.Iani, A.Juzeniene, P.Juzenas, L.-W.Ma and J.Moan (2006) The effect of dimethyl sulfoxide, 1-[2-(decylthio-)ethyl-]azacyclopentane-2-one and labrafac on porphyrin formation in mouse skin during topical application of methyl 5-aminolevulinate; a fluorescence and extraction study. Photodiagn. Photodyn. Ther. 3(1), 27-33.
48. R.F.Donnelly, P.A.McCarron, L.-W.Ma, P.Juzenas, V.Iani, J.Moan, A.A.Zawislak and A.D.Woolfson (2006) Facilitated Delivery of ALA to Inaccessible Regions via Bioadhesive Patch Systems. J. Environ. Pathol. Toxicol. Oncol. 25(1-2), 389-402.
47. L.Zhao, K.P.Nielsen, A.Juzeniene, P.Juzenas, V.lani, L.W.Ma, K.Stamnes, J.J.Stamnes and J.Moan (2006) Spectroscopic measurements of photoinduced processes in human skin after topical application of the hexylester of 5-aminolevulinic acid. J. Environ. Pathol. Toxicol. Oncol. 25(1-2), 307-320.
46. P.Juzenas and J.Moan (2006) Review. Singlet oxygen in photosensitization. J. Environ. Pathol. Toxicol. Oncol. 25(1-2), 29-50.
45. R.F.Donnelly, D.I.J.Morrow, P.A.McCarron, P.Juzenas and A.D.Woolfson (2006) Pharmaceutical analysis of 5-aminolevulinic acid in solution and in tissues. J. Photochem. Photobiol. B:Biol. 82(1), 59-71.
44. R.F.Donnelly, P.Juzenas, P.A.McCarron, A.D.Woolfson and J.Moan (2006) Review. Drug delivery for topical photodynamic therapy: Difficulties and novel solutions. In Trends in Cancer Research, Trivandrum, vol. 2, pp. 1-20.
43. P.Juzenas (2005) Review. Lasers in therapy of human diseases. In Trends in Cancer Research, Trivandrum, vol. 1, pp. 93-103.
42. K.P.Nielsen, A.Juzeniene, P.Juzenas, K.Stamnes, J.J.Stamnes and Johan Moan (2005) Choice of optimal wavelength for PDT: The significance of oxygen depletion. Photochem. Photobiol. 81(5), 1190-1194.
41. M.Kaliszewski, A.Juzeniene, P.Juzenas, M.Kwasny, J.Kaminski, Z.Dabrowski, J.Golinski and J.Moan (2005) Formation of protoporphyrin IX from carboxylic- and amino- derivatives of 5-aminolevulinic acid. Photodiagn. Photodynam. Ther. 2(2), 129-134.
40. P.Juzenas, A.Juzeniene and J.Moan (2005) Deferoxamine photosensitizes cancer cells in vitro. Biochem. Biophys. Res. Comm. 332(2), 388-391.
39. S.Kristiansson, A.Juzeniene, P.Juzenas, V.Iani, L.Löfgren and J.Moan (2005) Kinetics of protoporphyrin IX formation in rat oral mucosa and skin after application of 5-aminolevulinic acid and its methylester. Photochem. Photobiol. 81(2), 394-397.
38. J.P.Wold, A.Veberg, A.Nilsen, V.Iani, P.Juzenas and J.Moan (2005) The role of naturally occurring chlorophyll and porphyrins in light induced oxidation of dairy products. A study based on fluorescence spectroscopy and sensory analysis. Int. Dairy J. 15(4), 343-353.
37. A.Uzdensky, E.Kolpakova, A.Juzeniene, P.Juzenas and J.Moan (2005) The effect of sub-lethal ALA-PDT on cytoskeleton and adhesion of cultured human cancer cells. Biochim. Biophys. Acta 1722(1), 43-50.
36. A.Juzeniene, P.Juzenas, L.-W.Ma, V.Iani and J.Moan (2004) Effectiveness of CureLight lamps for 5-aminolevulinic acid photodynamic therapy. Lasers Med. Sci. 19(3), 139-149.
35. K.P.Nielsen, Z.Lu, P.Juzenas, J.J.Stamnes, K.Stamnes and J.Moan (2004) Reflectance spectra of pigmented and non-pigmented skin in the UV spectral region. Photochem. Photobiol. 80(3), 450-455.
34. A.B.Uzdensky, A.Juzeniene, E.Kolpakova, G.-O. Hjortland, P.Juzenas and J.Moan (2004) Photosensitization with protoporphyrin IX inhibits attachment of cancer cells to a substratum. Biochem. Biophys. Res. Comm. 322, 452-457.
33. P.Juzenas, A.Juzeniene, R.Rotomskis and J.Moan (2004) Spectroscopic evidence of monomeric aluminium phthalocyanine tetrasulphonate in aqueous solutions. J. Photochem. Photobiol. B:Biol. 75(1-2), 107-110.
32. J.Moan and P.Juzenas (2004) Biological effects from combinations of drugs and light. In: Photostability of drugs and drug formulations, 2nd edition. Ed. H.H.Tønnesen, CRC Press, Boca Raton, Florida, pp. 189-211.
31. J.Moan, B.Cunderlikova, A.Juzeniene, P.Juzenas, L.-W.Ma and V.Iani (2003) Tumour selectivity of photodynamic therapy. In Targeted Cancer Therapies - An Odyssey, Tromsø Symposium 2003 (June 22–24). Eds. Ø.S.Bruland and T.Flægstad. Ravnetrykk, Tromsø, pp. 208-213.
30. J.Moan, L.-W.Ma, A.Juzeniene, V.Iani, P.Juzenas, F.Apricena and Q.Peng (2003) Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters. Int. J. Cancer 103(1), 132-135.
29. A.Juzeniene, L.-W.Ma, P.Juzenas, V.Iani, N.Lange and J.Moan (2002) Production of protoporphyrin IX from 5-aminolevulinic acid and two of its esters in cells in vitro and tissues in vivo. Cell. Mol. Biol. 48(8), 911-916.
28. P.Juzenas (2002) Investigations of the endogenous photosensitizer protoporphyrin IX in hairless mouse skin by means of fluorescence spectroscopy. Dissertation for the Degree of Dr. Philos. Faculty of Mathematics and Natural Sciences, University of Oslo. No. 237, ISSN 1501-7710.
27. P.Juzenas, A.Juzeniene, S.Stakland, V.Iani and J.Moan (2002) Photosensitizing effect of protoporphyrin IX in pigmented melanoma of mice. Biochem. Biophys. Res. Comm. 297(3), 468-472.
26. P.Juzenas, A.Juzeniene, O.Kaalhus, V.Iani and J.Moan (2002) Noninvasive fluorescence excitation spectroscopy during application of 5-aminolevulinic acid in vivo. Photochem. Photobiol. Sci. 1(10), 745-748.
25. P.Juzenas, S.Sharfaei, J.Moan and R.Bissonnette (2002) Protoporphyrin IX fluorescence kinetics in UV-induced tumours and normal skin of hairless mice after topical application of 5-aminolevulinic acid methyl ester. J. Photochem. Photobiol. B:Biol. 67(1), 11-17.
24. S.Sharfaei, P.Juzenas, J.Moan and R.Bissonnette (2002) Weekly topical application of methyl aminolevulinate followed by light exposure delays the appearance of UV-induced skin tumours in mice. Arch. Dermatol. Res. 294, 237-242.
23. R.Bissonnette, J.-F.Tremblay, P.Juzenas, M.Boushira and H.Lui (2002) Systemic photodynamic therapy with aminolevulinic acid induces apoptosis in lesional T lymphocytes of psoriatic plaques. J. Invest. Dermatol. 119(1), 77-83.
22. A.Juzeniene, P.Juzenas, O.Kaalhus, V.Iani and J.Moan (2002) Temperature effect on accumulation of protoporphyrin IX after topical application of 5-aminolevulinic acid and its methylester and hexylester derivatives in normal mouse skin. Photochem. Photobiol. 76(4), 452-456.
21. A.Juzeniene, P.Juzenas, V.Iani and J.Moan (2002) Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin model. Photochem. Photobiol. 76(3) 329-334.
20. J.Moan, J.T.H.M. van den Akker, P.Juzenas, L.W.Ma, E.Angell-Petersen, ¨.B.Gadmar and V.Iani (2001) On the basis for tumor selectivity in the 5-aminolevulinic acid-induced synthesis of protoporphyrin IX. J. Porphyr. Phthalocyanines 5, 170-176.
19. P.Juzenas, V.Iani, S.Bagdonas, R.Rotomskis and J.Moan (2001) Fluorescence spectroscopy of normal mouse skin exposed to 5-aminolaevulinic acid and red light. J. Photochem. Photobiol. B:Biol. 61(1-2), 78-86.
18. M. von Beckerath, P.Juzenas, L.-W.Ma, V.Iani, L.Löfgren and J.Moan (2001) The influence of UV-exposure on 5-aminolevulinic acid-induced protoporphyrin IX production in skin. Photochem. Photobiol. 74(6), 825-828.
17. J.-F.Tremblay, G.Viau, P.Juzenas, H.Lui and R.Bissonnette (2001) Photodynamic therapy of psoriasis with oral aminolevulinic acid. J. Cutan. Med. Surg. 5(suppl.3, abstract), 55.
16. J.Moan, P.Juzenas, A.Juzeniene and L.W.Ma (2001) Mechanisms and procedures in photodynamic therapy. JEADV (J. Eur. Acad. Dermatol. Venereol.) 15(suppl.2, abstract), 78-79.
15. J.Moan, LW.Ma, V.Iani and P.Juzenas (2001) Mechanisms and Procedures in PDT. In Skin and Environment – Perception and Protection. 10th EADV Congress, Munich, 2001 (Munich, October 10-14, 2001), J.Ring, S.Weidinger, U.Darsow, Eds., pp. 641-647.
14. P.Juzenas, V.Iani and J.Moan (2000) Influence of temperature and anaesthesia on production of protoporphyrin IX induced by topical application of 5-aminolevulinic acid and its methylester in normal mouse skin. In Third Internet Conference on Photochemistry and Photobiology. http://www.photobiology.com/photobiology2000/juzenas
13. J.Moan, P.Juzenas and S.Bagdonas (2000) Review. Degradation and transformation of photosensitisers during light exposure. In Recent Research Developments in Photochemistry and Photobiology, Ed. S.G.Pandalai, Transworld Research Network, Trivandrum, Vol. 4, Part I, p. 121-132.
12. S.Bagdonas, L.-W.Ma, V.Iani, R.Rotomskis, P.Juzenas and J.Moan (2000) Phototransformations of 5-aminolevulinic acid-induced protoporphyrin IX in vitro: a spectroscopic study. Photochem. Photobiol. 72(2), 186-192.
11. G.Streckyte, D.Frolov, S.Bagdonas, P.Juzenas and R.Rotomskis (1999) Can photodynamic dose be predicted on sensitizer's photophysical parameters? In Second Internet Conference on Photochemistry and Photobiology, paper 40. http://www.photobiology.com/photobiology99
10. J.Moan, K.Berg, O.B.Gadmar, V.Iani, L.-W.Ma and P.Juzenas (1999) The temperature dependence of protoporphyrin IX production in cells and tissues. Photochem. Photobiol. 70(4), 669-673.
9. P.Juzenas, R.Sørensen, V.Iani and J.Moan (1999) Uptake of topically applied 5-aminolevulinic acid and production of protoporphyrin IX in normal mouse skin: dependence on skin temperature. Photochem. Photobiol. 69(4), 478-481.
8. P.Juzenas, S.Bagdonas, G.Streckyte, J.Moan and R.Rotomskis (1999) [Endogenous photosensitizer protoporphyrin IX in photosensitized tumour therapy]. Medicina 35(3), 189-195. (in Lithuanian)
7. R.Rotomskis, S.Bagdonas, P.Juzenas, D.Frolov and G.Streckyte (1999) Photomodification of sensitizers commonly used in photosensitized tumor therapy. In International Conference on Biomedical Optics, Q.Luo, B.Chance, L.V.Wang, S.L.Jacques, Eds., Proc. SPIE 3863, 489-495.
5. P.Juzenas, R.Sørensen, V.Iani and J.Moan (1999) Clearance of protoporphyrin IX from mouse skin after topical application of 5-aminolevulinic acid and its methyl ester. In Photochemotherapy of Cancer and Other Diseases, B.Ehrenberg, K.Berg, Eds., Proc. SPIE 3563, 161-166.
5. R.Sørensen, P.Juzenas, V.Iani and J.Moan (1999) Formation of protoporphyrin IX in mouse skin after topical application of 5-aminolevulinic acid and its methyl ester. In Photochemotherapy of Cancer and Other Diseases, B.Ehrenberg, K.Berg, Eds., Proc. SPIE 3563, 77-81.
4. P.Juzenas, S.Bagdonas, J.Didziapetriene, L.Staciokiene and R.Rotomskis (1997) Fluorescence spectroscopy of sensitized cancerous and normal tissues ex vivo. Acta Bio-Optica et Informatica Medica (Abstracts of the International Symposium on Photodynamic therapy, June 12-14, 1997, Wroclaw, Poland) 3, p. 17.
3. P.Juzenas, J.Didziapetriene, L.Staciokiene, V.Gudelis, J.Slavenas and R.Rotomskis (1996) Photomodifications of photodrugs in tumours. In Photochemotherapy: Photodynamic Therapy and Other Modalities, B.Ehrenberg, G.Jori, J.Moan, Eds., Proc. SPIE 2625, 499-506.
2. V.Gudelis, P.Juzenas, J.Slavenas, R.Rotomskis and J.Didziapetriene (1996) Investigation of fluorescence spectra of sensitized cancer tissues. Lith. J. Physics (Liet. Fiz. Z.) 36(4), 318-321.
1. V.Gudelis, P.Juzenas, J.Slavenas and R.Rotomskis (1995) [Fluorescence investigations of photosensitizers in cancerous cells]. In The materials of the 11th Belarussian-Lithuanian seminar “Lasers and optical non-linearity” (June 29-30, 1994, Minsk), 60-65. (in Russian)
 
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