Eva M. Wenzel
- Scientist (InvaCell)
- +47 22 78 18 19
From the news:
Nature Communications paper from Wenzel and Raiborg: Timing of growth factor receptor downregulation
Publication as Eva M. Kohler (2008-2010)
Kohler EM, Derungs A, Daum G, Behrens J, Schneikert J (2008). Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours. Hum Mol Genet, 17(13): 1978-1987
Kohler EM, Brauburger K, Behrens J, Schneikert J (2009). Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients. Oncogene, 29(11): 1663-1671
Kohler EM, Chandra SH, Behrens J, Schneikert J (2010). Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours. Hum Mol Genet, 18(2): 213-226
Welzel O, Tischbirek CH, Jung J, Kohler EM, Svetlitchny A, Henkel AW, Kornhuber J, Groemer TW (2010). Synapse clusters are preferentially formed by synapses with large recycling pool sizes. PLoS One, 5(10): e13514
Publications 2024
Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding
Nat Commun, 15 (1), 1277
DOI 10.1038/s41467-024-45558-8, PubMed 38341434
Publications 2023
Protrudin-mediated ER-endosome contact sites promote phagocytosis
Cell Mol Life Sci, 80 (8), 216
DOI 10.1007/s00018-023-04862-0, PubMed 37468729
Removal of hypersignaling endosomes by simaphagy
Autophagy, 20 (4), 769-791
DOI 10.1080/15548627.2023.2267958, PubMed 37840274
ATPase activity of DFCP1 controls selective autophagy
Nat Commun, 14 (1), 4051
DOI 10.1038/s41467-023-39641-9, PubMed 37422481
Publications 2022
Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease
Curr Opin Cell Biol, 75, 102062
DOI 10.1016/j.ceb.2022.01.007, PubMed 35248976
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
EMBO J, 41 (24), e112677
DOI 10.15252/embj.2022112677, PubMed 36408828
ER as master regulator of membrane trafficking and organelle function
J Cell Biol, 221 (10)
DOI 10.1083/jcb.202205135, PubMed 36108241
ER-endosome contacts master the ins and outs of secretory endosomes
J Cell Biol, 221 (12)
DOI 10.1083/jcb.202210033, PubMed 36355088
Publications 2021
Publisher Correction: Engineered bidirectional promoters enable rapid multi-gene co-expression optimization
Nat Commun, 12 (1), 1287
DOI 10.1038/s41467-021-21369-z, PubMed 33602905
Publications 2020
Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles
Proc Natl Acad Sci U S A, 117 (46), 28614-28624
DOI 10.1073/pnas.2014228117, PubMed 33139578
Clathrin regulates Wnt/β-catenin signaling by affecting Golgi to plasma membrane transport of transmembrane proteins
J Cell Sci, 133 (13)
DOI 10.1242/jcs.244467, PubMed 32546530
Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion
J Cell Biol, 219 (8)
DOI 10.1083/jcb.202003063, PubMed 32479595
Publications 2019
ESCRT-mediated phagophore sealing during mitophagy
Autophagy, 16 (5), 826-841
DOI 10.1080/15548627.2019.1639301, PubMed 31366282
Publications 2018
ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival
EMBO J, 37 (21)
DOI 10.15252/embj.201899753, PubMed 30314966
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation
Nat Commun, 9 (1), 2932
DOI 10.1038/s41467-018-05345-8, PubMed 30050131
Publications 2017
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
Nat Cell Biol, 19 (12), 1412-1423
DOI 10.1038/ncb3631, PubMed 29084199
Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation
PLoS One, 12 (1), e0170508
DOI 10.1371/journal.pone.0170508, PubMed 28107521
Publications 2016
Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery
Trends Biochem Sci, 42 (1), 42-56
DOI 10.1016/j.tibs.2016.08.016, PubMed 27669649
ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission
J Cell Biol, 212 (5), 499-513
DOI 10.1083/jcb.201507009, PubMed 26929449
Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity
PLoS One, 11 (8), e0160507
DOI 10.1371/journal.pone.0160507, PubMed 27482906
Phosphoinositides in membrane contact sites
Biochem Soc Trans, 44 (2), 425-30
DOI 10.1042/BST20150190, PubMed 27068950
ER-endosome contact sites in endosome positioning and protrusion outgrowth
Biochem Soc Trans, 44 (2), 441-6
DOI 10.1042/BST20150246, PubMed 27068952
Publications 2015
Surface Trafficking of APP and BACE in Live Cells
Traffic, 16 (6), 655-75
DOI 10.1111/tra.12270, PubMed 25712587
Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth
Nature, 520 (7546), 234-8
DOI 10.1038/nature14359, PubMed 25855459
ER-endosome contact sites: molecular compositions and functions
EMBO J, 34 (14), 1848-58
DOI 10.15252/embj.201591481, PubMed 26041457
Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes
Mol Cancer Res, 13 (11), 1487-501
DOI 10.1158/1541-7786.MCR-15-0125, PubMed 26124443
Publications 2014
The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons
PLoS One, 9 (8), e103976
DOI 10.1371/journal.pone.0103976, PubMed 25133820
different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli
PLoS One, 9 (4), e94413
DOI 10.1371/journal.pone.0094413, PubMed 24722208
Publications 2013
Basic presynaptic functions in hippocampal neurons are not affected by acute or chronic lithium treatment
J Neural Transm (Vienna), 121 (2), 211-9
DOI 10.1007/s00702-013-1087-9, PubMed 24036894
Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation
PLoS One, 8 (7), e68072
DOI 10.1371/journal.pone.0068072, PubMed 23840886
Publications 2012
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
EMBO Rep, 14 (1), 57-64
DOI 10.1038/embor.2012.183, PubMed 23154468
Use-dependent inhibition of synaptic transmission by the secretion of intravesicularly accumulated antipsychotic drugs
Neuron, 74 (5), 830-44
DOI 10.1016/j.neuron.2012.04.019, PubMed 22681688
Key physiological parameters dictate triggering of activity-dependent bulk endocytosis in hippocampal synapses
PLoS One, 7 (6), e38188
DOI 10.1371/journal.pone.0038188, PubMed 22675521
Publications 2010
Synapse clusters are preferentially formed by synapses with large recycling pool sizes
PLoS One, 5 (10), e13514
DOI 10.1371/journal.pone.0013514, PubMed 20976002
Publications 2009
Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients
Oncogene, 29 (11), 1663-71
DOI 10.1038/onc.2009.447, PubMed 19966865
Publications 2008
Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours
Hum Mol Genet, 18 (2), 213-26
DOI 10.1093/hmg/ddn338, PubMed 18854359
Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours
Hum Mol Genet, 17 (13), 1978-87
DOI 10.1093/hmg/ddn095, PubMed 18387968