Radiumhospitalet

Matthias Kolberg
Position:	Senior scientist
Phone:	+47 2278 1730
Email:

Room K04 057

Research interests:
Functional and structural analyses of proteins related to cell growth and cancer (TP53 network). Colorectal cancer and soft tissue sarcomas. Immunohistochemical protein expression analyses using tissue microarrays.

Academic degree:
2001: Ph.D. (Dr.rer.nat.) – Physical Biochemistry, Max-Volmer Laboratory, Technical University Berlin, Germany.

Theses:
M. Kolberg (2001)
Generation and Characterization of Free and Metal Associated Amino Acid Radicals in Ribonucleotide Reductase Using EPR Techniques.
Doctoral dissertation, Fakultät II - Technische Universität Berlin.

M. Kolberg (1997)
Fraksjonering og karakterisering av proteinkomponenter i alkenmonooksygenase fra Mycobacterium E3.
Cand. scient. thesis, University of Oslo

Previous positions:
Post doctoral fellowship, Department of Molecular Biosciences, University of Oslo.

List of Publications:

H. R. Brekke, M. Kolberg, R. I. Skotheim, K. S. Hall, B. Bjerkehagen, B. Risberg, H. A. Domanski, N. Mandahl, K. Liestøl, S. Smeland, H. V. Danielsen, F. Mertens, R. A. Lothe (2009)
Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors.
Neuro Oncol. 11:514-528

G. E. Lind, T. Ahlquist, M. Kolberg, M. Berg, M. Eknæs, M. A. Alonso, A. Kallioniemi, G. I. Meling, R. I. Skotheim, T. O. Rognum, E. Thiis-Evensen, R. A. Lothe (2008)
Hypermethylated MAL gene - a silent marker of early colon tumorigenesis.
J. Translat. Med. 6:13

M.Kolberg, Å. K. Røhr, F. H. Cederkvist, K. R. Strand, K. K. Andersson (2008)
Recent Studies of Class I RNR.
In: Ribonucleotide Reductase (Ed.: K. K. Andersson), Nova Science Publishers Inc, Hauppauge, NY, pp. 173-184

F. F. Miranda, M. Kolberg, K. K. Andersson, C. F. G. C. Geraldes, and A. Martínez (2005)
The Active Site Residue Tyrosine 325 Influences Iron Binding and Coupling Efficiency in Human Phenylalanine Hydroxylase.
J. Inorg. Biochem. 99: 1320-1328

M. Kolberg, D. T. Logan, G. Bleifuss, S. Pötsch, B.-M. Sjöberg, A. Gräslund, W. Lubitz, G. Lassmann, and F. Lendzian (2005)
A New Tyrosyl Radical on F208 as Ligand to the Diiron Center in E. coli Ribonucleotide Reductase, Mutant R2-Y122H: Combined X-ray Diffraction, and EPR/ENDOR Studies.
J. Biol. Chem 280: 11233-11246

E. S. Ryabova, P. Rydberg, M. Kolberg, E. Harbitz, K. K. Andersson, A.-L. Barra, and E. Nordlander (2005)
A Comparative Reactivity Study of Microperoxidases Based on Hemin, Mesohemin and Deuterohemin.
J. Inorg. Biochem. 99: 852-863

M. Kolberg, K. R. Strand, P. Graff, and K. K. Andersson (2004)
Structure, Function, and Mechanism of Ribonucleotide Reductases.
Biochim. Biophys. Acta 1699: 1-34

K. R. Strand, S. Karlsen, M. Kolberg, Å. K. Røhr, C. H. Görbitz and K. K. Andersson (2004)
Crystal Structural Studies of Changes in the Native Dinuclear Iron Center of Ribonucleotide Reductase Protein R2 from Mouse.
J. Biol. Chem. 279: 46794-46801

A. Engalytcheff, M. Kolberg, A.-L. Barra, K. K. Andersson, and B. Tilquin (2004)
The Use of Multi-frequency EPR Techniques to Identify the Radicals Produced in Irradiated β-Blockers.
Free Rad. Res. 38: 59-66

M. Högbom, M. Andersson, M. Galander, M. Kolberg, W. Hofbauer, G. Lassmann, P. Nordlund, and F. Lendzian (2003)
Displacement of the Tyrosyl Radical Cofactor in Ribonucleotide Reductase Obtained from Single-Crystal High-Field EPR and 1.4 Å X-Ray Data.
Proc. Natl. Acad. Sci. USA. 100: 3209-3214

G. Lassmann, M. Kolberg, G. Bleifuss, A. Gräslund, B.-M. Sjöberg, and W. Lubitz (2003)
Protein Thiyl Radicals in Disordered Systems: A Comparative EPR Study at Low Temperature.
Phys. Chem. Chem. Phys. 5: 2442-2453

M. Kolberg, G. Bleifuss, A. Gräslund, B.-M. Sjöberg, W. Lubitz, F. Lendzian, and G. Lassmann (2002)
Protein Thiyl Radicals Observed Directly by EPR Spectroscopy.
Arch. Biochem. Biophys. 403: 141-144

M. Kolberg, G. Bleifuss, B.-M. Sjöberg, A. Gräslund, W. Lubitz, F. Lendzian, and G. Lassmann (2002)
Generation and EPR Spin Trapping Detection of Thiyl Radicals in Model Proteins and the R1 Protein of E. coli Ribonucleotide Reductase.
Arch. Biochem. Biophys. 397: 57-68

G. Bleifuss, M. Kolberg, S. Pötsch, W. Hofbauer, W. Lubitz, A. Gräslund, G. Lassmann, and F. Lendzian (2001)
Tryptophan and Tyrosine Radicals in Ribonucleotide Reductase: A Comparative High-Field EPR Study at 94 GHz.
Biochemistry 40: 15362-15368

M. Kolberg, G. Bleifuss, S. Pötsch, A. Gräslund, W. Lubitz, G. Lassmann, and F. Lendzian (2000)
A New Stable High-Valent Diiron Center in R2 Mutant Y122H of E. coli Ribonucleotide Reductase Studied by High-Field EPR and ⁵⁷Fe-ENDOR.
J. Am. Chem. Soc. 122: 9856-9857

Scientific contributions to commercial adds:

Oxford Instruments, UK
ESR 900/910 Cryostats for Electron Spin Resonance Spectroscopy

Publications 2010

Brekke HR, Ribeiro FR, Kolberg M, Agesen TH, Lind GE, Eknaes M, Hall KS, Bjerkehagen B, van den Berg E, Teixeira MR, Mandahl N, Smeland S, Mertens F, Skotheim RI, Lothe RA (2010)
Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
J Clin Oncol, 28 (9), 1573-82
PubMed 20159821

Publications 2009

Brekke HR, Kolberg M, Skotheim RI, Hall KS, Bjerkehagen B, Risberg B, Domanski HA, Mandahl N, Liestøl K, Smeland S, Danielsen HE, Mertens F, Lothe RA (2009)
Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
Neuro Oncol, 11 (5), 514-28
PubMed 19182148

Publications 2008

Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO, Thiis-Evensen E, Lothe RA (2008)
Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
J Transl Med, 6, 13
PubMed 18346269

Publications 2005

Kolberg M, Logan DT, Bleifuss G, Pötsch S, Sjöberg BM, Gräslund A, Lubitz W, Lassmann G, Lendzian F (2005)
A new tyrosyl radical on Phe208 as ligand to the diiron center in Escherichia coli ribonucleotide reductase, mutant R2-Y122H. Combined x-ray diffraction and EPR/ENDOR studies
J Biol Chem, 280 (12), 11233-46
PubMed 15634667

Miranda FF, Kolberg M, Andersson KK, Geraldes CF, Martínez A (2005)
The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase
J Inorg Biochem, 99 (6), 1320-8
PubMed 15917086

Ryabova ES, Rydberg P, Kolberg M, Harbitz E, Barra AL, Ryde U, Andersson KK, Nordlander E (2005)
A comparative reactivity study of microperoxidases based on hemin, mesohemin and deuterohemin
J Inorg Biochem, 99 (3), 852-63
PubMed 15708807

Publications 2004

Engalytcheff A, Kolberg M, Barra AL, Andersson KK, Tilquin B (2004)
The use of multi-frequency EPR techniques to identify the radicals produced in irradiated beta-blockers
Free Radic Res, 38 (1), 59-66
PubMed 15061654

Kolberg M, Strand KR, Graff P, Andersson KK (2004)
Structure, function, and mechanism of ribonucleotide reductases
Biochim Biophys Acta, 1699 (1-2), 1-34
PubMed 15158709

Strand KR, Karlsen S, Kolberg M, Røhr AK, Görbitz CH, Andersson KK (2004)
Crystal structural studies of changes in the native dinuclear iron center of ribonucleotide reductase protein R2 from mouse
J Biol Chem, 279 (45), 46794-801
PubMed 15322079

Publications 2003

Högbom M, Galander M, Andersson M, Kolberg M, Hofbauer W, Lassmann G, Nordlund P, Lendzian F (2003)
Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-A x-ray data
Proc Natl Acad Sci U S A, 100 (6), 3209-14
PubMed 12624184

Publications 2002

Kolberg M, Bleifuss G, Gräslund A, Sjöberg BM, Lubitz W, Lendzian F, Lassmann G (2002)
Protein thiyl radicals directly observed by EPR spectroscopy
Arch Biochem Biophys, 403 (1), 141-4
PubMed 12061811

Kolberg M, Bleifuss G, Sjöberg BM, Gräslund A, Lubitz W, Lendzian F, Lassmann G (2002)
Generation and electron paramagnetic resonance spin trapping detection of thiyl radicals in model proteins and in the R1 subunit of Escherichia coli ribonucleotide reductase
Arch Biochem Biophys, 397 (1), 57-68
PubMed 11747310

Feb 6, 2006 [3720 visits]

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