Late normal tissue toxicity
In modern radiotherapy a common strategy for improving the therapeutic ratio, i.e. the probability of local tumour control or survival vs. late toxicity, is to reduce the irradiated volume of normal tissues and organs. The underlying assumption for this strategy is that the organ or tissue in question possesses a fair volume effect. To utilize this strategy a detailed knowledge about the nature of late effects is crucial. Late normal tissue response following radiation therapy depends on numerous factors, such as total dose, dose pr. fraction, irradiated volume and functional architecture of the tissue.
The aim of our research is to:
Read more about:
- Rectal toxicity
- Lung toxicity
- Dose to the contralateral breast and risk estimation
The aim of our research is to:
- unveil the relationship between the normal tissue volume effect and the functional architecture.
- establish bio-mathematical models incorporating tissue architecture.
- develop strategies for optimizing dose distributions reducing late normal sequela.
Read more about:
- Rectal toxicity
- Lung toxicity
- Dose to the contralateral breast and risk estimation
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