The Proteomics & Mammalian Cell Biology Section functions as a core facility for cancer proteomics at The Norwegian Radium Hospital. Furnished with a MALDI-TOF mass spectrometer and equipment for two-dimensional gel electrophoresis, the section explores the possibility of using large-scale proteomic analysis as a cancer diagnostic tool, and provides proteomic service (e.g., protein identification by tryptic peptide mass fingerprinting) for cancer researchers and other scientists at the University of Oslo.

In the section's own research projects, proteomics is used to study autophagic protein degradation in normal and malignant liver cells, and the role of phosphorylation-based signalling pathways (in particular the stress-activated AMPK pathway) in the regulation of autophagy, apoptosis (programmed cell death), and cytoskeletal organization.

 

 

Contact information:
Department of Cell Biology, Institute for Cancer Research,
The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway
Email Per.O.Seglen@rr-reserach.no, Phone:+47 22 78 19 80, Fax: +47 22 78 19 95