Randi Gussgard
Syljuåsen
Fax: +4722781207
CV
Education:
Ph.D., University of California, Los Angeles, 1996. Thesis: ”Studies of Intrinsic Radiosensitivity”, Supervisor: Prof. W.H. McBride, Dept Radiation Oncology.
Sivilingeniør (M.Sc), Biophysics, The Norwegian Institute of Technology, 1991. Thesis: ”Optical Trapping”, Supervisor: Prof. T. Lindmo, Dept Biophysics.
Previous positions:
2007 (6 months): Guest researcher, BRIC Biocenter, Copenhagen University, Denmark (Claus Sørensen´s group).
1999-2006: Postdoctoral Researcher, Dept Cell Cycle and Cancer, The Danish Cancer Society, Copenhagen, Denmark (Jiri Bartek&Jiri Lukas´s group).
1997-1998 (14 months): Postdoc, Laboratory of Radiobiology, Harvard School of Public Health, Boston, USA (John B. Little´s group).
1996-1997: Postdoc, Dept Radiation Oncology, UCLA, USA (William McBride´s group).
Fellowships:
Sept 2007-Aug 2010: Senior Scientist Fellowship, The Norwegian Cancer Society, Norway.
2004-2005: Postdoctoral Fellowship, The Danish Medical Research Council, Denmark.
2002-2003 and 1999: Alfred Benzon Investigator Fellowship, Alfred Benzon Foundation, Denmark.
2000-2001: Marie Curie Individual Fellowship, The European Commission.
1995-1996: Seed Grant Fellowship, Johnsson Comprehensive Cancer Center Foundation, UCLA, USA.
1991-1994: Graduate student individual fellowship, The Norwegian Research Council, Norway.
1991: Generaldirektør Østbyes Fellowship, The Norwegian Institute of Technology, Norway.
Awards:
2005: The Varian Juliana Denekamp Award, European Society for Therapeutic Radiation Oncology.
1995: Sylvia Sorkin Greenfield Memorial Award, UCLA Biomedical Physics.
1995: Louis B. Silverman Award, Health Physics Society, Southern California.
Ph.D., University of California, Los Angeles, 1996. Thesis: ”Studies of Intrinsic Radiosensitivity”, Supervisor: Prof. W.H. McBride, Dept Radiation Oncology.
Sivilingeniør (M.Sc), Biophysics, The Norwegian Institute of Technology, 1991. Thesis: ”Optical Trapping”, Supervisor: Prof. T. Lindmo, Dept Biophysics.
Previous positions:
2007 (6 months): Guest researcher, BRIC Biocenter, Copenhagen University, Denmark (Claus Sørensen´s group).
1999-2006: Postdoctoral Researcher, Dept Cell Cycle and Cancer, The Danish Cancer Society, Copenhagen, Denmark (Jiri Bartek&Jiri Lukas´s group).
1997-1998 (14 months): Postdoc, Laboratory of Radiobiology, Harvard School of Public Health, Boston, USA (John B. Little´s group).
1996-1997: Postdoc, Dept Radiation Oncology, UCLA, USA (William McBride´s group).
Fellowships:
Sept 2007-Aug 2010: Senior Scientist Fellowship, The Norwegian Cancer Society, Norway.
2004-2005: Postdoctoral Fellowship, The Danish Medical Research Council, Denmark.
2002-2003 and 1999: Alfred Benzon Investigator Fellowship, Alfred Benzon Foundation, Denmark.
2000-2001: Marie Curie Individual Fellowship, The European Commission.
1995-1996: Seed Grant Fellowship, Johnsson Comprehensive Cancer Center Foundation, UCLA, USA.
1991-1994: Graduate student individual fellowship, The Norwegian Research Council, Norway.
1991: Generaldirektør Østbyes Fellowship, The Norwegian Institute of Technology, Norway.
Awards:
2005: The Varian Juliana Denekamp Award, European Society for Therapeutic Radiation Oncology.
1995: Sylvia Sorkin Greenfield Memorial Award, UCLA Biomedical Physics.
1995: Louis B. Silverman Award, Health Physics Society, Southern California.
Publication list
1. R.G. Syljuåsen. Checkpoint adaptation in human cells. Oncogene, 26, p.5833-5839, 2007.
2. R.G. Syljuåsen, S. Jensen, J. Bartek and J. Lukas. Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on Chk1 and Plk1 kinases. Cancer Research, 66, p. 10253-10257, 2006.
3. R.G. Syljuåsen, C.S. Sørensen*, L.T. Hansen, K.Fugger, C. Lundin, F. Johansson, T. Helleday, M. Sehested, J. Lukas, and J. Bartek. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Molecular and Cellular Biology, 25, p.3553-3562, 2005.
4. C.S. Sørensen, L.T. Hansen, J. Dziegielewski, R.G. Syljuåsen, C. Lundin, J. Bartek, and T. Helleday. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nature Cell Biology, 7, p. 195-201, 2005.
5. R.G. Syljuåsen, C.S. Sørensen, J. Nylandsted, C. Lukas, J.Lukas, and J.Bartek. Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing radiation. Cancer Research, 64, p. 9035-9040, 2004.
6. A. Kramer, N. Mailand, C. Lukas, R.G. Syljuåsen, C.J. Wilkinson, E.A. Nigg, J. Bartek, and J. Lukas. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nature Cell Biology, 6, p.884-891, 2004.
7. C.S. Sørensen, R.G. Syljuåsen, J. Lukas, and J. Bartek. ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle, 3, p. 941-945, 2004.
8. H. Löffler, R.G. Syljuåsen, J. Bartkova, J. Worm, J. Lukas, and J. Bartek. Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines. Oncogene, 22, p.8063-8071, 2003.
9. W.H. McBride, K.S. Iwamoto, R. Syljuåsen, M. Pervan, F. Pajonk. The role of the ubiquitin/proteasome system in cellular responses to radiation. Oncogene, 37, p.5755-5773, 2003.
10. C.S. Sørensen, R.G. Syljuåsen, J. Falck, T. Schroeder, L. Rönnstrand, K.K. Khanna, B.B. Zhou, J. Bartek, and J. Lukas. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell, 3, p. 247-258, 2003.
11. M. Gatei, K. Sloper, C. Sørensen, R. Syljuåsen, J. Falck , K. Hobson, K. Savage, J. Lukas, B.B. Zhou , J. Bartek, and K.K. Khanna. Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. Journal of Biological Chemistry, 278, p.14806-14811, 2003.
12. J. Falck, N. Mailand, R. G. Syljuåsen, J. Bartek and J. Lukas. The Chk2-cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature, 410, p.842-847, 2001.
13. R. G. Syljuåsen, B. Krolewski and J. B. Little. Molecular events in radiation transformation. Radiation Research, 155, p. 215-221, 2001.
14. N. Mailand, J. Falck, C. Lukas, R. G. Syljuåsen, M. Welcker, J. Bartek and J. Lukas. Rapid destruction of human cdc25A in response to DNA damage. Science, 288, p. 1425-1429, 2000.
15. Y. E. Whang, C. Tran, C. Henderson, R. G. Syljuåsen, N. Rozengurt, W. H. McBride and C. L. Sawyers. C-Abl is required for development and optimal cell proliferation in the context of p53 deficiency. Proceedings of the National Academy of Sciences of the United States of America, 97, p.5486-5491, 2000.
16. R.G. Syljuåsen and W.H. McBride. Radiation-induced apoptosis and cell cycle arrest in Jurkat T cells. Radiation Research, 152, p.328-331, 1999.
17. R.G. Syljuåsen, B. Krolewski and J. B. Little. Loss of normal G1 checkpoint control is an early step in carcinogenesis, independent of p53-status. Cancer Research, 59, p.1008-1014, 1999.
18. W.H. McBride, G.J. Dougherty, R.G. Syljuåsen, C.S. Chiang and J.L. Daigle. New molecular and genetic approaches aimed at improving radiation therapy. In Proceedings of 6th International Meeting on Progress in Radio-Oncology, p.27-33, 1998.
19. R.G. Syljuåsen, A. Belldegrun, C-L. Tso, H.R. Withers and W.H. McBride: Sensitization of renal carcinoma to radiation using alpha interferon (IFNA) gene transfection. Radiation Research, 148, p.443-448, 1997.
20. C-S. Chiang, R.G. Syljuåsen, J-H. Hong, A. Wallis, G.J. Dougherty and W.H. McBride: Effects of IL-3 gene expression on tumor response to irradiation in Vitro and in Vivo. Cancer Research, 57, 3899-3903, 1997.
21. R.G. Syljuåsen, J-H. Hong and W.H. McBride: Apoptosis and delayed expression of c-jun and c-fos after gamma irradiation of Jurkat T cells. Radiation Research, 146, 276-282, 1996.
22. W.H. McBride, J.S. Economou, R.G. Syljuåsen, C. Parrish, D. Hackman, V. Latham, C-S. Chiang and G.J. Dougherty: The effects of cytokine gene transfer into tumors on host cell infiltration and regression. Anticancer Research, 16, 1139-1144, 1996.
23. W. H. McBride, J.S. Economou, N. Kuber, J-H. Hong, C-S. Chiang, R.G. Syljuåsen, S. Dougherty and G.J. Dougherty. Modification of tumor microenvironment by cytokine gene transfer. Acta Oncologia, Vol.34, No.3, 447-451, 1995.
24. R. Gussgard, T. Lindmo and I. Brevik: Calculation of the trapping force in a strongly focused laser beam. J. Opt.Soc.Am. B., Vol.9, No.10, 1922-1930, 1992.
2. R.G. Syljuåsen, S. Jensen, J. Bartek and J. Lukas. Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on Chk1 and Plk1 kinases. Cancer Research, 66, p. 10253-10257, 2006.
3. R.G. Syljuåsen, C.S. Sørensen*, L.T. Hansen, K.Fugger, C. Lundin, F. Johansson, T. Helleday, M. Sehested, J. Lukas, and J. Bartek. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Molecular and Cellular Biology, 25, p.3553-3562, 2005.
4. C.S. Sørensen, L.T. Hansen, J. Dziegielewski, R.G. Syljuåsen, C. Lundin, J. Bartek, and T. Helleday. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nature Cell Biology, 7, p. 195-201, 2005.
5. R.G. Syljuåsen, C.S. Sørensen, J. Nylandsted, C. Lukas, J.Lukas, and J.Bartek. Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing radiation. Cancer Research, 64, p. 9035-9040, 2004.
6. A. Kramer, N. Mailand, C. Lukas, R.G. Syljuåsen, C.J. Wilkinson, E.A. Nigg, J. Bartek, and J. Lukas. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nature Cell Biology, 6, p.884-891, 2004.
7. C.S. Sørensen, R.G. Syljuåsen, J. Lukas, and J. Bartek. ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle, 3, p. 941-945, 2004.
8. H. Löffler, R.G. Syljuåsen, J. Bartkova, J. Worm, J. Lukas, and J. Bartek. Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines. Oncogene, 22, p.8063-8071, 2003.
9. W.H. McBride, K.S. Iwamoto, R. Syljuåsen, M. Pervan, F. Pajonk. The role of the ubiquitin/proteasome system in cellular responses to radiation. Oncogene, 37, p.5755-5773, 2003.
10. C.S. Sørensen, R.G. Syljuåsen, J. Falck, T. Schroeder, L. Rönnstrand, K.K. Khanna, B.B. Zhou, J. Bartek, and J. Lukas. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell, 3, p. 247-258, 2003.
11. M. Gatei, K. Sloper, C. Sørensen, R. Syljuåsen, J. Falck , K. Hobson, K. Savage, J. Lukas, B.B. Zhou , J. Bartek, and K.K. Khanna. Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. Journal of Biological Chemistry, 278, p.14806-14811, 2003.
12. J. Falck, N. Mailand, R. G. Syljuåsen, J. Bartek and J. Lukas. The Chk2-cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature, 410, p.842-847, 2001.
13. R. G. Syljuåsen, B. Krolewski and J. B. Little. Molecular events in radiation transformation. Radiation Research, 155, p. 215-221, 2001.
14. N. Mailand, J. Falck, C. Lukas, R. G. Syljuåsen, M. Welcker, J. Bartek and J. Lukas. Rapid destruction of human cdc25A in response to DNA damage. Science, 288, p. 1425-1429, 2000.
15. Y. E. Whang, C. Tran, C. Henderson, R. G. Syljuåsen, N. Rozengurt, W. H. McBride and C. L. Sawyers. C-Abl is required for development and optimal cell proliferation in the context of p53 deficiency. Proceedings of the National Academy of Sciences of the United States of America, 97, p.5486-5491, 2000.
16. R.G. Syljuåsen and W.H. McBride. Radiation-induced apoptosis and cell cycle arrest in Jurkat T cells. Radiation Research, 152, p.328-331, 1999.
17. R.G. Syljuåsen, B. Krolewski and J. B. Little. Loss of normal G1 checkpoint control is an early step in carcinogenesis, independent of p53-status. Cancer Research, 59, p.1008-1014, 1999.
18. W.H. McBride, G.J. Dougherty, R.G. Syljuåsen, C.S. Chiang and J.L. Daigle. New molecular and genetic approaches aimed at improving radiation therapy. In Proceedings of 6th International Meeting on Progress in Radio-Oncology, p.27-33, 1998.
19. R.G. Syljuåsen, A. Belldegrun, C-L. Tso, H.R. Withers and W.H. McBride: Sensitization of renal carcinoma to radiation using alpha interferon (IFNA) gene transfection. Radiation Research, 148, p.443-448, 1997.
20. C-S. Chiang, R.G. Syljuåsen, J-H. Hong, A. Wallis, G.J. Dougherty and W.H. McBride: Effects of IL-3 gene expression on tumor response to irradiation in Vitro and in Vivo. Cancer Research, 57, 3899-3903, 1997.
21. R.G. Syljuåsen, J-H. Hong and W.H. McBride: Apoptosis and delayed expression of c-jun and c-fos after gamma irradiation of Jurkat T cells. Radiation Research, 146, 276-282, 1996.
22. W.H. McBride, J.S. Economou, R.G. Syljuåsen, C. Parrish, D. Hackman, V. Latham, C-S. Chiang and G.J. Dougherty: The effects of cytokine gene transfer into tumors on host cell infiltration and regression. Anticancer Research, 16, 1139-1144, 1996.
23. W. H. McBride, J.S. Economou, N. Kuber, J-H. Hong, C-S. Chiang, R.G. Syljuåsen, S. Dougherty and G.J. Dougherty. Modification of tumor microenvironment by cytokine gene transfer. Acta Oncologia, Vol.34, No.3, 447-451, 1995.
24. R. Gussgard, T. Lindmo and I. Brevik: Calculation of the trapping force in a strongly focused laser beam. J. Opt.Soc.Am. B., Vol.9, No.10, 1922-1930, 1992.
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