New randomized trial on cancer risk following polyp removal during colonoscopy published in NEJM: 99 percent of patients with polyps did NOT have bowel cancer after 5 years

Mette Kalager, leader of the Clinical Effectiveness group
Mette Kalager, leader of the Clinical Effectiveness group

The European Polyp Surveillance (EPoS) study is the world’s largest randomized study project investigating the follow-up of patients with colorectal polyps. The project involves nearly 21,000 patients across eight European countries. On September 17, The New England Journal of Medicine published two scientific articles presenting the initial results from the EPoS study. The EPoS project is led by the Clinical Effectiveness Research Group at Oslo University Hospital and the University of Oslo. EPoS could mean that millions of people worldwide who have had intestinal polyps removed require fewer colonoscopies than they do today. This saves hospitals money and reduces the burden and potential complications for patients. The results are expected to change clinical practice globally.

Links:

The New England Journal of Medicine article:
Colonoscopy Intervals and Colorectal Cancer Incidence after Adenoma Removal
Authors: Rodrigo Jover, M.D., Ph.D., Michael Bretthauer, M.D., Ph.D., Joaquin Cubiella, M.D., Ph.D., Sarah J.E. Barry, Ph.D., Anna Macios, Ph.D., Lauren Barnett, Ph.D., Rune Erichsen, M.D., Ph.D., +30 , for the EPoS Study 
N Engl J Med 2026;395:1051-1061
DOI: 10.1056/NEJMoa2603816, VOL. 395 NO. 11

Popular science articles about the findings, in Norwegian:

Forskningsnytt, University of Oslo:
Vil redusere koloskopikontroller etter fjerning av tarmpolypper (uio.no)

OUS Innsikt:
Kan redusere antall koloskopikontroller etter fjerning av tarmpolypper (oslo-universitetssykehus.no)

Dagens Medisin (subscription required):
Tarmkreft: Ikke høyere kreftrisiko med sjeldnere koloskopi (dagensmedisin.no)

Summary of the findings/press release, from the authors (PDF)


Clinical Effectiveness Research (med.uio.no)

Clinical Effectiveness Research (ous-research.no)

Mette Kalager (ous-research.no)

Michael Bretthauer (ous-research.no)