Publications 2026

Valestrand L, Nordhus KS, Claudel T, Øgaard J, Frank A, Amundsen-Isaksen E, Fuchs C, Berntsen NL, Chung BK, Jiang X, Trauner M, Melum E (2026)
Natural Killer T cells promote cholestatic liver disease independent of antigen presentation by cholangiocytes
Hepatol Commun, 10 (2)
DOI 10.1097/HC9.0000000000000862, PubMed 41543487

Publications 2025

Chung BK, Jördens MS, Øgaard J, Reims HM, Flateland B, Luedde T, Jiang X, Karlsen TH, Melum E (2025)
Multimodal transcriptomics identifies metallothionein as a novel pathway in primary sclerosing cholangitis
Hepatology (in press)
DOI 10.1097/HEP.0000000000001432, PubMed 40560681

Publications 2024

Oldereid TS, Jiang X, Øgaard J, Schrumpf E, Bjørnholt JV, Rasmussen H, Melum E (2024)
Microbial exposure during early life regulates development of bile duct inflammation
Scand J Gastroenterol, 59 (2), 192-201
DOI 10.1080/00365521.2023.2278423, PubMed 37997753

Publications 2023

Jiang X, Otterdal K, Chung BK, Maucourant C, Rønneberg JD, Zimmer CL, Øgaard J, Boichuk Y, Holm S, Geanon D, Schneditz G, Bergquist A, Björkström NK, Melum E (2023)
Cholangiocytes Modulate CD100 Expression in the Liver and Facilitate Pathogenic T-Helper 17 Cell Differentiation
Gastroenterology, 166 (4), 667-679
DOI 10.1053/j.gastro.2023.11.283, PubMed 37995866

Oldereid TS, Jiang X, Nordhus KS, Ponzetta A, Bjørnholt JV, Björkström NK, Melum E, Rasmussen H (2023)
Role of bacteria and microbial metabolites in immune modulation during early life
Scand J Immunol, 99 (2), e13336
DOI 10.1111/sji.13336, PubMed 38441196

Publications 2022

Valestrand L, Zheng F, Hansen SH, Øgaard J, Hov JR, Björkström NK, Karlsen TH, Jiang X, Melum E (2022)
Bile from Patients with Primary Sclerosing Cholangitis Contains Mucosal-Associated Invariant T-Cell Antigens
Am J Pathol, 192 (4), 629-641
DOI 10.1016/j.ajpath.2021.12.008, PubMed 35063408

Publications 2021

Jiang X, Bergquist A, Löscher BS, Venkatesh G, Mold JE, Holm K, Laerdahl JK, Skånland SS, Maleki KT, Cornillet M, Taskén K, Franke A, Karlsen TH, Björkström NK, Melum E (2021)
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Sci Transl Med, 13 (582)
DOI 10.1126/scitranslmed.abb0036, PubMed 33627483

Jiang X, Melum E (2021)
The Role of Natural Killer Cells in Nonalcoholic Steatohepatitis: An Ongoing Debate
Cell Mol Gastroenterol Hepatol, 13 (1), 348-349
DOI 10.1016/j.jcmgh.2021.10.006, PubMed 34740615

Publications 2020

Valestrand L, Berntsen NL, Zheng F, Schrumpf E, Hansen SH, Karlsen TH, Blumberg RS, Hov JR, Jiang X, Melum E (2020)
Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells
Clin Exp Immunol, 203 (2), 304-314
DOI 10.1111/cei.13541, PubMed 33089489

Publications 2019

Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS (2019)
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin
Nat Immunol, 20 (12), 1644-1655
DOI 10.1038/s41590-019-0504-0, PubMed 31636468

Publications 2018

Berntsen NL, Fosby B, Tan C, Reims HM, Ogaard J, Jiang X, Schrumpf E, Valestrand L, Karlsen TH, Line PD, Blumberg RS, Melum E (2018)
Natural killer T cells mediate inflammation in the bile ducts
Mucosal Immunol, 11 (6), 1582-1590
DOI 10.1038/s41385-018-0066-8, PubMed 30115993

Publications 2017

Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J et al. (2017)
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598, PubMed 28779025

Jiang X, Björkström NK, Melum E (2017)
Intact CD100-CD72 Interaction Necessary for TCR-Induced T Cell Proliferation
Front Immunol, 8, 765
DOI 10.3389/fimmu.2017.00765, PubMed 28713384

Jiang X, Karlsen TH (2017)
Genetics of primary sclerosing cholangitis and pathophysiological implications
Nat Rev Gastroenterol Hepatol, 14 (5), 279-295
DOI 10.1038/nrgastro.2016.154, PubMed 28293027

Schrumpf E, Jiang X, Zeissig S, Pollheimer MJ, Anmarkrud JA, Tan C, Exley MA, Karlsen TH, Blumberg RS, Melum E (2017)
The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation
Physiol Rep, 5 (4)
DOI 10.14814/phy2.13117, PubMed 28219981