Publications 2025

Mauthe M, van de Beek N, Mari M, Korsten G, Nobari P, Castelino KB, de Mattos EP, Ouhida I, Dijkstra JL, Schipper-Krom S, de la Ballina LR, Mueller MR, Simonsen A, Hipp MS, Kapitein LC, Kampinga HH, Reggiori F (2025)
A chaperone-proteasome-based fragmentation machinery is essential for aggrephagy
Nat Cell Biol, 27 (9), 1448-1464
DOI 10.1038/s41556-025-01747-1, PubMed 40866512

Publications 2023

Creamer A, Fiego AL, Agliano A, Prados-Martin L, Høgset H, Najer A, Richards DA, Wojciechowski JP, Foote JEJ, Kim N, Monahan A, Tang J, Shamsabadi A, Rochet LNC, Thanasi IA, de la Ballina LR, Rapley CL, Turnock S, Love EA, Bugeon L, Dallman MJ, Heeney M, Kramer-Marek G, Chudasama V, Fenaroli F et al. (2023)
Modular Synthesis of Semiconducting Graft Copolymers to Achieve "Clickable" Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting
Adv Mater, 36 (20), e2300413
DOI 10.1002/adma.202300413, PubMed 36905683

Holme B, Bjørnerud B, Pedersen NM, de la Ballina LR, Wesche J, Haugsten EM (2023)
Automated tracking of cell migration in phase contrast images with CellTraxx
Sci Rep, 13 (1), 22982
DOI 10.1038/s41598-023-50227-9, PubMed 38151514

Kaur N, de la Ballina LR, Haukaas HS, Torgersen ML, Radulovic M, Munson MJ, Sabirsh A, Stenmark H, Simonsen A, Carlsson SR, Lystad AH (2023)
TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy
EMBO J, 42 (17), e113105
DOI 10.15252/embj.2022113105, PubMed 37409525

Publications 2022

Maestro I, de la Ballina LR, Porras G, Corrochano S, De Lago E, Simonsen A, Boya P, Martinez A (2022)
Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations
Int J Mol Sci, 23 (20)
DOI 10.3390/ijms232012676, PubMed 36293534

Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Simonsen A (2022)
GAK and PRKCD kinases regulate basal mitophagy
Autophagy, 18 (2), 467-469
DOI 10.1080/15548627.2021.2015154, PubMed 35001811

Søreng K, Pankiv S, Bergsmark C, Haugsten EM, Dahl AK, de la Ballina LR, Yamamoto A, Lystad AH, Simonsen A (2022)
ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration
J Cell Sci, 135 (4)
DOI 10.1242/jcs.259138, PubMed 35099014

Publications 2021

Maestro I, de la Ballina LR, Simonsen A, Boya P, Martinez A (2021)
Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease
ACS Chem Neurosci, 12 (24), 4512-4523
DOI 10.1021/acschemneuro.1c00529, PubMed 34846852

Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Schultz SW, Aman Y, Lystad AH, Singh S, Singh S, Wesche J, Fang EF, Simonsen A (2021)
GAK and PRKCD are positive regulators of PRKN-independent mitophagy
Nat Commun, 12 (1), 6101
DOI 10.1038/s41467-021-26331-7, PubMed 34671015

Publications 2019

de la Ballina LR, Munson MJ, Simonsen A (2019)
Lipids and Lipid-Binding Proteins in Selective Autophagy
J Mol Biol, 432 (1), 135-159
DOI 10.1016/j.jmb.2019.05.051, PubMed 31202884

Holdgaard SG, Cianfanelli V, Pupo E, Lambrughi M, Lubas M, Nielsen JC, Eibes S, Maiani E, Harder LM, Wesch N, Foged MM, Maeda K, Nazio F, de la Ballina LR, Dötsch V, Brech A, Frankel LB, Jäättelä M, Locatelli F, Barisic M, Andersen JS, Bekker-Jensen S, Lund AH, Rogov VV, Papaleo E et al. (2019)
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
Nat Commun, 10 (1), 4176
DOI 10.1038/s41467-019-12094-9, PubMed 31519908

Lystad AH, Carlsson SR, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, Melia TJ, Simonsen A (2019)
Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes
Nat Cell Biol, 21 (3), 372-383
DOI 10.1038/s41556-019-0274-9, PubMed 30778222

Publications 2018

Boulter E, Estrach S, Tissot FS, Hennrich ML, Tosello L, Cailleteau L, de la Ballina LR, Pisano S, Gavin AC, Féral CC (2018)
Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway
Nat Commun, 9 (1), 4862
DOI 10.1038/s41467-018-07268-w, PubMed 30451822

Publications 2017

Hernández-Alvarez MI, Díaz-Ramos A, Berdasco M, Cobb J, Planet E, Cooper D, Pazderska A, Wanic K, O'Hanlon D, Gomez A, de la Ballina LR, Esteller M, Palacin M, O'Gorman DJ, Nolan JJ, Zorzano A (2017)
Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism
Sci Rep, 7 (1), 13850
DOI 10.1038/s41598-017-14120-6, PubMed 29062026

Publications 2016

Cormerais Y, Giuliano S, LeFloch R, Front B, Durivault J, Tambutté E, Massard PA, de la Ballina LR, Endou H, Wempe MF, Palacin M, Parks SK, Pouyssegur J (2016)
Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
Cancer Res, 76 (15), 4481-92
DOI 10.1158/0008-5472.CAN-15-3376, PubMed 27302165

de la Ballina LR, Cano-Crespo S, González-Muñoz E, Bial S, Estrach S, Cailleteau L, Tissot F, Daniel H, Zorzano A, Ginsberg MH, Palacín M, Féral CC (2016)
Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability
J Biol Chem, 291 (18), 9700-11
DOI 10.1074/jbc.M115.704254, PubMed 26945935

Publications 2007

Fort J, de la Ballina LR, Burghardt HE, Ferrer-Costa C, Turnay J, Ferrer-Orta C, Usón I, Zorzano A, Fernández-Recio J, Orozco M, Lizarbe MA, Fita I, Palacín M (2007)
The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane
J Biol Chem, 282 (43), 31444-52
DOI 10.1074/jbc.M704524200, PubMed 17724034

Publications 2004

Masson V, de la Ballina LR, Munaut C, Wielockx B, Jost M, Maillard C, Blacher S, Bajou K, Itoh T, Itohara S, Werb Z, Libert C, Foidart JM, Noël A (2004)
Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes
FASEB J, 19 (2), 234-6
DOI 10.1096/fj.04-2140fje, PubMed 15550552